23/01/2021

Bioinformatics dissection of aberrant developmental progression during tumorigenesis using a single-cell multi-omics approach

This job offer has expired


  • ORGANISATION/COMPANY
    TAGC/INSERM U1090
  • RESEARCH FIELD
    Biological sciencesBiological engineering
    Biological sciencesBiology
    Computer scienceInformatics
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
    Recognised Researcher (R2)
    Established Researcher (R3)
    Leading Researcher (R4)
  • APPLICATION DEADLINE
    26/02/2021 00:00 - Europe/Athens
  • LOCATION
    France › Marseille
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • OFFER STARTING DATE
    01/09/2021

OFFER DESCRIPTION

We are proposing a PhD position to investigate, at the single cell level, the gene regulatory regions controlling brain development and tumorigenesis in Drosophila. For this purpose, we will use a single-cell multi-omics approach (RNA-seq and ATAC-seq).

Recent single-cell transcriptomics data have shown that brain cancers in children are driven by aberrantly redeployed developmental programs. However, it is still unclear how these developmental programs are coopted and regulated in the tumorigenic context. Brain development is understood in unmatched details in Drosophila where we have recently generated a model of brain tumors that recapitulates childhood tumors. New technologies now allow the simultaneous analysis of the transcriptome and regulome (regulatory regions) in single-cells. This project aims to generate and analyze single-cell data from neural progenitors isolated from the developing brain and tumors in Drosophila. The student will prepare tissues for high-throughput sequencing (HTS). He will then carry out a bioinformatics analysis to identify gene regulatory regions and infer gene regulatory networks involved during  normal brain development and brain tumorigenesis. This project will shed light on how developmental programs can be coopted to promote tumorigenesis in children.

 



Funding category: Contrat doctoral

Turing Centre for Living Systems (CENTURI)

PHD title: Doctorat de Bioinformatique

PHD Country: France

More Information

Offer Requirements

Specific Requirements

The PhD candidate should have a Master's degree in an area related to Bioinformatics, Biophysics, or Computer Science with a strong interest in data analysis. Previous experimental experience is not required but the student should be motivated to embark on a substantial amount of experimental work in order to generate the single-cell data to be analyzed.

Work location(s)
1 position(s) available at
TAGC/INSERM U1090
France
Marseille

EURAXESS offer ID: 597882
Posting organisation offer ID: 95664

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